https://doi.org/10.4081/cardio.2024.36

Prevalence of left ventricular dysfunction and relationship with serum selenium in apparently healthy pregnant women: results from the PEACE registry

Vol. 2 No. 2 (2024)
Published: June 28 2024
Left ventricular dysfunction, pregnancy, selenium, peripartum cardiomyopathy, PEACE registry
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Authors

Kamilu M. Karaye
kkaraye@yahoo.co.uk
Bayero University, Kano, Nigeria; Aminu Kano Teaching Hospital, Kano, Nigeria; Department of Public Health and Clinical Medicine, Umea University, Sweden.
Idris Y. Mohammed
Bayero University, Kano; Aminu Kano Teaching Hospital, Kano, Nigeria.
Hadiza Sa’idu
Bayero University, Kano; Murtala Mohammed Specialist Hospital, Kano, Nigeria.
Naser A. Ishaq
Aminu Kano Teaching Hospital, Kano, Nigeria.
Suleiman A. Balarabe
Mohammed Abdullahi Wase Specialist Hospital, Kano, Nigeria.
Jamilu Tukur
Bayero University, Kano; Aminu Kano Teaching Hospital, Kano, Nigeria.
Tewogbade A. Adedeji
Obafemi Awolowo University Teaching Hospital Complex, Ile Ife, Nigeria.
Olufemiwa N. Makinde
Obafemi Awolowo University Teaching Hospital Complex, Ile Ife, Nigeria.
Rasaaq A. Adebayo
Obafemi Awolowo University Teaching Hospital Complex, Ile Ife, Nigeria.

Background: Peripartum cardiomyopathy (PPCM) is common in North-West Nigeria and many affected patients have selenium deficiency. It is not known whether asymptomatic cardiac dysfunction related to selenium deficiency commonly starts during pregnancy in the region. The study aimed to determine the prevalence of left ventricular (LV) systolic and diastolic dysin apparently healthy pregnant women and if there is relationship with serum selenium, in a society with high prevalence of PPCM.
Methods: This was a prospective longitudinal study carried out in 3 centers in Kano, Nigeria. 108 apparently healthy pregnant women were consecutively recruited between the 28th and 38th weeks of gestation and reevaluated at the 6th to 8th weeks postpartum. Serum selenium was measured at enrolment during pregnancy. LV systolic dysfunction was defined as LV ejection fraction (LVEF) below 50% and LV diastolic dysfunction was defined and graded according to the recommendations of the American Society of Echocardiography.
Results: LV systolic dysfunction and diastolic dysfunction were found in 6 subjects (5.6%) and 20 subjects (18.5%) during pregnancy, and in 9 subjects (10.2%; p=0.340) and 14 (15.9%; p=0.631) of them after delivery, respectively. Mean LVEF was 62.2±6.9% and 60.6±8.2% (p=0.108) during pregnancy and after delivery respectively. Mean LV end-diastolic dimension measured during pregnancy (48.6±4.9 mm) was not significantly difference with what was obtained after delivery (47.2±6.9 mm) (p=0.099). Mean left atrial size (37.0±4.8 mm vs. 35.2±4.8 mm; p<00.1) and mitral septal E/e’ ratio (8.4±2.8 vs. 1.3±0.5; p<0.001) were higher during pregnancy than after delivery, respectively. Selenium deficiency (<70 μg/L) was found in only 2.8% of subjects, and serum selenium did not significantly correlate with indices for LVEF or diastolic (mitral E/e’ ratio) functions both during pregnancy and after delivery.
Conclusions: LV systolic and diastolic dysfunction and selenium deficiency were uncommon during apparently healthy pregnancy and early puerperium, and serum selenium did not correlate with indices for LV function, in a population with high prevalence of PPCM.

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Scopus
Google Scholar
Europe PMC
Sanghavi M, Rutherford JD. Cardiovascular physiology of pregnancy. Circulation 2014;130:1003-8. DOI: https://doi.org/10.1161/CIRCULATIONAHA.114.009029
Melchiorre K, Sharma R, Khalil A, Thilaganathan B. Maternal cardiovascular function in pregnancy. Evidence of maladaptation to chronic volume overload. Hypertension 2016;67:754-62. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.06667
Sliwa K, Hilfiker-Kleiner D, Petrie MC, Mebazaa A, Pieske B, Buchmann E, et al. Heart Failure Association of the European Society of Cardiology Working Group on Peripartum Cardiomyopathy. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail 2010;12:767-78. DOI: https://doi.org/10.1093/eurjhf/hfq120
Arany Z, Elkayam U. Peripartum cardiomyopathy. Circulation 2016;133:1397-409. DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.020491
Karaye KM, Yahaya IA, Lindmark K, Lindmark K, Henein MY. Serum selenium and ceruloplasmin in Nigerians with peripartum cardiomyopathy. Int J Mol Sci 2015;16:7644-54. DOI: https://doi.org/10.3390/ijms16047644
Karaye KM, Ishaq NA, Sa'idu H, Balarabe SA, Talle MA, Isa MS, et al; PEACE Registry Investigators. Incidence, clinical characteristics, and risk factors of peripartum cardiomyopathy in Nigeria: results from the peripartum cardiomyopathy in Nigeria Registry. ESC Heart Fail 2020;7:235-43. DOI: https://doi.org/10.1002/ehf2.12562
Karaye KM, Mohammed IY, Ogah OS, Okeahialam BN. Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry. Int Cardiovasc Forum J 2017;12:12-7. DOI: https://doi.org/10.17987/icfj.v12i0.462
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015;28:1-39. DOI: https://doi.org/10.1016/j.echo.2014.10.003
Kadish AH, Buxton AE, Kennedy HL, Knight BP, Mason JW, Schuger CD, et al. ACC/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: a report of the American College of Cardiology/American Heart Association/American College of Physicians − American Society of Internal Medicine Task Force on Clinical Competence (ACC/AHA Committee to Develop a Clinical Competence Statement on Electrocardiography and Ambulatory Electrocardiography). J Am Coll Cardiol 2001;38:2091-100. DOI: https://doi.org/10.1016/S0735-1097(01)01680-1
World Medical Association. Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects. J Postgrad Med 2002;48:206-8.
Cenac A, Simonoff M, Moretto P, Djibo A. A low plasma selenium is a risk factor for peripartum cardiomyopathy. A comparative study in Sahelian Africa. Int J Cardiol 1992;36:57-9. DOI: https://doi.org/10.1016/0167-5273(92)90108-F
Robson SC, Hunter S, Moore M, Dunlop W. Haemodynamic changes during the puerperium: a Doppler and M-mode echocardiographic study. Br J Obstet Gynaecol 1987;94:1028-39. DOI: https://doi.org/10.1111/j.1471-0528.1987.tb02286.x
Ducas RA, Elliott JE, Melnyk SF, Premecz S, daSilva M, Cleverley K, et al. Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study. J Cardiovasc Magn Reson 2014;16:1. DOI: https://doi.org/10.1186/1532-429X-16-1
Umar S, Nadadur R, Iorga A, Amjedi M, Matori H, Eghbali M. Cardiac structural and hemodynamic changes associated with physiological heart hypertrophy of pregnancy are reversed postpartum. J Appl Physiol 2012;113:1253-59. DOI: https://doi.org/10.1152/japplphysiol.00549.2012
Nwagha UI, Ogbodo SO, Nwogu-Ikojo EE, Ibegbu DM, Ejezie FE, Nwagha TU, et al. Copper and selenium status of healthy pregnant women in Enugu, south-eastern Nigeria. Niger J Clin Pract 2011;14:408-12. DOI: https://doi.org/10.4103/1119-3077.91745
Adeniyi MJ, Agoreyo FO. Nigeria and the selenium micronutrient: a review. Curr Trends Biomed Eng Biosci 2018;14:555876. DOI: https://doi.org/10.19080/CTBEB.2018.14.555876
Diaz-Alarcon JP, Navarro-Alarcon M, Lopez-Ga de la Serrana H, Lopez-Martinez MC. Determination of selenium in meat products by hydride generation atomic absorption spectrometry: selenium levels in meats, organ meats, and sausages in Spain. J Agric Food Chem 1996;44:1494-7. DOI: https://doi.org/10.1021/jf950702l
Li Y, Yang Y, Chen H. [Detection of enteroviral RNA in paraffin-embedded myocardial tissue from patients with Keshan by nested PCR]. Zhonghua Yi Xue Za Zhi 1995;75:344-5. [Article in Chinese].
Peng T, Li Y, Yang Y, et al. Characterization of enterovirus isolates from patients with heart muscle disease in a selenium deficient area of China. J Clin Microbiol 2000;38:3538-43. DOI: https://doi.org/10.1128/JCM.38.10.3538-3543.2000
Davidson NM, Hudson B, Parry EHO. Defaulters from follow-up after peripartum cardiac failure. Trop Geogr Med 1975;27:103-8.

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Prevalence of left ventricular dysfunction and relationship with serum selenium in apparently healthy pregnant women: results from the PEACE registry. (2024). Global Cardiology, 2(2). https://doi.org/10.4081/cardio.2024.36
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