https://doi.org/10.4081/cardio.2024.42
Clinical profiles and short-term outcomes of women with peripartum and dilated cardiomyopathies
Published: November 5, 2024
Abstract Views: 1618
PDF: 454
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Background: We aimed to compare the clinical and sociodemographic characteristics, rate of left ventricular reverse remodeling (LVRR), heart failure hospitalization and allcause mortality of women with peripartum and dilated cardiomyopathies (PPCM and DCM respectively) in Nigeria. Methods: This was a prospective longitudinal study and a total of 130 patients (65 for each group) were recruited consecutively and followed up for 6 months. Results: PPCM patients were younger, but the DCM patients had higher frequency of atrial fibrillation and complete left bundle branch block, higher mean left atrial and LV dimensions, higher LV filling pressures, and worse renal dysfunction, respectively, at baseline. At the end of the 6month followup, 15 female DCM vs 21 PPCM patients (p=0.684) had achieved LVRR, 13 DCM vs 11 PPCM patients (p=0.098) were hospitalized for heart failure, and 10 DCM vs 5 PPCM patients (p=0.098) had died. The odds for achieving LVRR was independently increased by systolic blood pressure (SBP) >100 mmHg and tricuspid annular plane systolic excursion >16 mm at baseline in PPCM patients, and by use of angiotensin converting enzyme inhibitors at baseline in female DCM patients. The odds for mortality were increased by tachycardia and pericardial effusion and reduced by the use of loop diuretics at baseline in DCM patients, and SBP <90 mmHg at baseline increased it by 9fold in PPCM patients. Conclusions: Our results suggest that women with DCM and PPCM differ significantly in their demographic and clinical characteristics, and predictors of clinical outcomes.
Sliwa K, Hilfiker-Kleiner D, Petrie MC, Mebazaa A, Pieske B, Buchmann E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail 2010;12:767-78.
DOI: https://doi.org/10.1093/eurjhf/hfq120
Karaye KM, Yahaya IA, Lindmark K, Henein MY. Serum selenium and ceruloplasmin in Nigerians with peripartum cardiomyopathy. Int J Mol Sci 2015;16:7644-54.
DOI: https://doi.org/10.3390/ijms16047644
Karaye KM, Ishaq NA, Saidu H, Balarabe SA, Talle MA, Isa MS. et al. Incidence, clinical characteristics, and risk factors of peripartum cardiomyopathy in Nigeria: results from the PEACE registry. ESC Heart Failure 2020;7:236-44.
DOI: https://doi.org/10.1002/ehf2.12562
Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, Böhm M, et al. Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur Heart J 2016;37:1850-8.
DOI: https://doi.org/10.1093/eurheartj/ehv727
Sliwa K, Damasceno A, Mayosi BM. Epidemiology and etiology of cardiomyopathy in Africa. Circulation 2005;112:3577-83.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.542894
Hershberger RE, Hedges DJ, Morales A. Dilated cardiomyopathy: the complexity of a diverse genetic architecture. Nat Rev Cardiol 2013;10:531-47.
DOI: https://doi.org/10.1038/nrcardio.2013.105
Karaye KM, Saidu H, Habib AG. Peripartum and other cardiomyopathies in a Nigerian adult population. Int J Cardiol 2011;147:342-3.
DOI: https://doi.org/10.1016/j.ijcard.2011.01.004
Dec GW, Fuster V. Idiopathic dilated cardiomyopathy. N Engl J Med 1994;331:1564-75.
DOI: https://doi.org/10.1056/NEJM199412083312307
Lu C, Lee W, Wu M, Chen S, Yeh J, Cheng C, et al. Comparison of clinical outcomes in peripartum cardiomyopathy and age-matched dilated cardiomyopathy. Medicine 2017;96:19.
DOI: https://doi.org/10.1097/MD.0000000000006898
Petryka-Mazurkiewicz J, Kryczka K, Mazurkiewicz Ł, Miłosz-Wieczorek B, Śpiewak M, Marczak M, et al. Cardiovascular magnetic resonance in peripartum cardiomyopathy: comparison with idiopathic dilated cardiomyopathy. Diagnostics (Basel) 2021;11:1752.
DOI: https://doi.org/10.3390/diagnostics11101752
World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. J Postgrad Med 2002;48:206-8.
Karaye KM, Lindmark K, Henein MY. One-year survival in Nigerians with peripartum cardiomyopathy. Heart Views 2016;17:55-61.
DOI: https://doi.org/10.4103/1995-705X.185114
Masci PG, Schuurman R, Andrea B, Ripoli A, Coceani M, Chiappino S, et al. Myocardial fibrosis as a key determinant of left ventricular remodeling in idiopathic dilated cardiomyopathy. Circ Cardiovasc Imaging 2013;6:790-9.
DOI: https://doi.org/10.1161/CIRCIMAGING.113.000438
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015;28:1-39.
DOI: https://doi.org/10.1016/j.echo.2014.10.003
Kadish AH, Buxton AE, Kennedy HL, Knight BP, Mason JW, Schuger CD, et al. ACC/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: a report of the American College of Cardiology/American Heart Association/American College of Physicians American Society of Internal Medicine Task Force on Clinical Competence (ACC/AHA Committee to develop a clinical competence statement on electrocardiography and ambulatory electrocardiography). J Am Coll Cardiol 2001;38:2091-100.
DOI: https://doi.org/10.1016/S0735-1097(01)01680-1
Karaye KM. Right ventricular systolic function in peripartum and dilated cardiomyopathies. Eur J Echocardiogr 2011;12:372-4.
DOI: https://doi.org/10.1093/ejechocard/jer024
Karaye KM, Shehu MN, Ngantcha M, Bonny A, Awad AM. Peripartum cardiomyopathy: a review article. West Afr J Med 2023;40:104-13.
Getz KD, Lewey J, Tam V, Irizarry OC, Levine LD, Aplenc R, et al. Neighborhood education status drives racial disparities in clinical outcomes in PPCM. Am Heart J 2021;238:27-32.
DOI: https://doi.org/10.1016/j.ahj.2021.03.015
Merlo M, Pyxaras SA, Pinamonti B, Barbati G, Di Lenarda A, Sinagra G. Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment. J Am Coll Cardiol 2011;57:1468-76.
DOI: https://doi.org/10.1016/j.jacc.2010.11.030
Fett JD, Christie LG, Carraway RD, Murphy JG. Five-year prospective study of the incidence and prognosis of peripartum cardiomyopathy at a single institution. Mayo Clin Proc 2005;80:1602-6.
DOI: https://doi.org/10.4065/80.12.1602
Blauwet LA, Libhaber E, Forster O, Tibazarwa K, Mebazaa A, HilfikerKleiner D, et al. Predictors of outcome in 176 South African patients with peripartum cardiomyopathy. Heart 2013;99:308-13.
DOI: https://doi.org/10.1136/heartjnl-2012-302760
McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, et al. clinical outcomes for peripartum cardiomyopathy in North America: results of the IPAC study (Investigations of Pregnancy-Associated Cardiomyopathy). J Am Coll Cardiol 2015;66:905-14.
DOI: https://doi.org/10.1016/j.jacc.2015.06.1309
Moulig V, Pfeffer TJ, Ricke-Hoch M. Long-term follow-up in peripartum cardiomyopathy patients with contemporary treatment: low mortality, high cardiac recovery, but significant cardiovascular co-morbidities. Eur J Heart Fail 2019;21:1534-42.
DOI: https://doi.org/10.1002/ejhf.1624
Karaye KM, Sa'idu H, Balarabe SA, Ishaq NA, Adamu UG, Mohammed IY, et al. Clinical features and outcomes of peripartum cardiomyopathy in Nigeria. J Am Coll Cardiol 2020;76:2352-64.
DOI: https://doi.org/10.1016/j.jacc.2020.09.540
Sliwa K, Forster O, Libhaber E. Peripartum cardiomyopathy: inflammatory markers as predictors of outcome in 100 prospectively studied patients. Eur Heart J 2006;27:441-6.
DOI: https://doi.org/10.1093/eurheartj/ehi481
How to Cite
Muhammad, B., Ishaq, N. A., & Karaye, K. M. (2024). Clinical profiles and short-term outcomes of women with peripartum and dilated cardiomyopathies. Global Cardiology, 2(3). https://doi.org/10.4081/cardio.2024.42
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Maryanne Caruana, Miriam Gatt, Oscar Aquilina, Charles Savona Ventura, Victor Grech, Jane Somerville, The impact of maternal congenital heart disease on pregnancy outcomes in Malta: a retrospective study , Global Cardiology: Vol. 1 No. 1 (2023)
- Kamilu M. Karaye, Idris Y. Mohammed, Okechukwu S. Ogah, Basil N. Okeahialam, Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry , Global Cardiology: Vol. 1 No. 1 (2023)
- Tariq Jamal Siddiqi, Javed Butler, Andrew J.S. Coats, Subodh Verma, Tim Friede, Gerasimos Filippatos, Stefan D. Anker, SGLT2 inhibitors and risk reduction for mortality in high-risk patients: a meta-analysis of randomized controlled trials , Global Cardiology: Vol. 1 No. 1 (2023)
- Reinaldo B. Bestetti, Rosemary Furlan-Daniel, Luciano P. Pereira, COVID-19 myocarditis , Global Cardiology: Vol. 2 No. 1 (2024)
- Emanuele Monda, Giuseppe Limongelli, Unveiling the genetic aetiology of non-genetic dilated cardiomyopathy , Global Cardiology: Vol. 2 No. 4 (2024)
- Stefan Peters, Encasement of the left anterior descending coronary artery: association with Takotsubo syndrome, and diagnostic and therapeutic options , Global Cardiology: Vol. 1 No. 1 (2023)
- Kamilu M. Karaye, Abdulrazaq G. Habib, Karen Sliwa, Epidemiology of peripartum cardiomyopathy in Africa , Global Cardiology: Vol. 2 No. 2 (2024)
- Stephan von Haehling, Wolfram Doehner, Ruben Evertz, Tania Garfias-Veitl, Monika Diek, Mahir Karakas, Ralf Birkemeyer, Gerasimos Fillippatos, Piotr Ponikowski, Michael Böhm, Tim Friede, Stefan D. Anker, Iron deficiency in heart failure with preserved ejection fraction: rationale and design of the FAIR-HFpEF trial , Global Cardiology: Vol. 1 No. 1 (2023)
- Eirini Flouda, Athena Stefanatou, Tinia Apergi, Intervention options: depression and cardiovascular disease during COVID-19 , Global Cardiology: Vol. 1 No. 1 (2023)
- Kamilu M. Karaye, Idris Y. Mohammed, Hadiza Sa’idu, Naser A. Ishaq, Suleiman A. Balarabe, Jamilu Tukur, Tewogbade A. Adedeji, Olufemiwa N. Makinde, Rasaaq A. Adebayo, Prevalence of left ventricular dysfunction and relationship with serum selenium in apparently healthy pregnant women: results from the PEACE registry , Global Cardiology: Vol. 2 No. 2 (2024)
You may also start an advanced similarity search for this article.
