https://doi.org/10.4081/cardio.2024.47
Depression, health-related quality of life and life satisfaction in patients with heart failure
Published: November 5, 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Background: The Patient Health Questionnaire 9 (PHQ9) has been recognized as an effective tool for identification of patients with heart failure (HF) at risk for lower health-related quality of life (HRQoL). We aimed to compare HRQoL levels, overall satisfaction with health and life, disease severity variables, sociodemographic variables and behavioural risk factors between patients with HF with different levels of depressive symptomatology. Methods: In a >55 years-old general population cross-sectional HF prevalence study, 1851 subjects were screened and those with NTproBNP ≥125 pg/mL (n=930) underwent detailed diagnostic visit to confirm or rule out HF as per 2016 European Society of Cardiology guidelines. HRQoL (the ShortForm 12 Health Survey, SF12; EQ5D3L), depressive symptoms (Patient Health Questionnaire, PHQ9) and satisfaction with life (Satisfaction With Life Scale, SWLS) were also assessed. Patient with HF (75±8 years, 54 % male, New York Heart Association (NYHA) functional class IIII, with mean left ventricular ejection fraction (LVEF) 56±13) were divided into three groups based on the severity of depressive symptomatology as per PHQ9 score (none: score 04, mild: score 59, and moderate-to-severe: score 1027). Multiple group comparisons and pairwise post hoc analyses were performed. Results: Results indicated significant between group differences in NYHA status (p<0.001), number of comorbidities (p=0.006), functional capacity (p=0.01), as well as HRQoL variables (p=0.05 to 0.001) and SWLS score (p<0.05), with nondepressed group generally showing better physical and subjective indicators of health and wellbeing compared with the mild and moderate-to-severe group. Conclusions: Results indicate that even patients with HF with clinically non-significant levels of depressive symptomatology show significantly impaired psychosocial status (diminished HRQoL, lower life satisfaction).
Bui, AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol 2011;8:30-41.
DOI: https://doi.org/10.1038/nrcardio.2010.165
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH. Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review. Eur J Heart Fail 2016;18:242-52.
DOI: https://doi.org/10.1002/ejhf.483
Ponikowski P, Voors AA, Anker SD, et al. Guidelines for the diagnosis and treatment of acute and chronic heart failure The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology ( ESC ) Developed with the special contribution. Eur J Heart Fail 2016;18:891-975.
DOI: https://doi.org/10.1002/ejhf.592
Omersa D, Farkas J, Erzen I, Lainscak M. National trends in heart failure hospitalization rates in Slovenia 2004-2012. Eur J Heart Fail 2016;18:1321-8.
DOI: https://doi.org/10.1002/ejhf.617
Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014;63:1123-33.
DOI: https://doi.org/10.1016/j.jacc.2013.11.053
Celano CM, Villegas AC, Albanese AM, Gaggin MD, Huffman JC. Depression and anxiety in heart failure: a review. Harv Rev Psychiatry 2018;26:175-84.
DOI: https://doi.org/10.1097/HRP.0000000000000162
Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure: a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 2006;48:1527-37.
DOI: https://doi.org/10.1016/j.jacc.2006.06.055
Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. Prevalence of depression in the community from 30 countries between 1994 and 2014. Sci Rep 2018;8:2861.
DOI: https://doi.org/10.1038/s41598-018-21243-x
Daskalopoulou M, George J, Walters K, et al. Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: data linkage study of 1.9 million women and men. PLoS One 2016; 22:e0153838.
DOI: https://doi.org/10.1371/journal.pone.0153838
Song EK, Lennie TA, Moser DK. Depressive symptoms increase risk of rehospitalisation in heart failure patients with preserved systolic function. J Clin Nurs 2009;18:1871-7.
DOI: https://doi.org/10.1111/j.1365-2702.2008.02722.x
Frasure-Smith N, Lespérance F, Habra M, et al. Elevated depression symptoms predict long-term cardiovascular mortality in patients with atrial fibrillation and heart failure. Circulation 2009;120:134-40.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.109.851675
Pelle AJ, Gidron YY, Szabó BM, Denollet J. Psychological predictors of prognosis in chronic heart failure. J Card Fail 2008;14:341-50.
DOI: https://doi.org/10.1016/j.cardfail.2008.01.004
Müller-Tasch T, Peters-Klimm F, Schellberg D, et al. Depression is a major determinant of quality of life in patients with chronic systolic heart failure in general practice. J Card Fail 2007;13:818-24.
DOI: https://doi.org/10.1016/j.cardfail.2007.07.008
Huffman JC, Smith FA, Blais MA, Beiser ME, Januzzi JL, Fricchione GL. Recognition and treatment of depression and anxiety in patients with acute myocardial infarction. Am J Cardiol 2006;98:319-24.
DOI: https://doi.org/10.1016/j.amjcard.2006.02.033
Lainscak M, Omersa D, Sedlar N, Anker SD, Farkas J. Heart failure prevalence in the general population: SOBOTA‐HF study rationale and design. ESC Heart Fail 2019;6:1077-84.
DOI: https://doi.org/10.1002/ehf2.12496
Babor TF, Higgins-Biddle JC, Monteiro MG. AUDIT: The alcohol use disorders identification test: Guidelines for use in primary care (second edition). Geneva, World Health Organization; 2001.
Bradley KA, DeBenedetti AF, Volk RJ, Williams EC, Frank D, Kivlahan DR. AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res 2007;31:1208-17.
DOI: https://doi.org/10.1111/j.1530-0277.2007.00403.x
Demers C, McKelvie RS, Negassa A, Yusuf S. Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure. Am Heart J 2001;142:698-703.
DOI: https://doi.org/10.1067/mhj.2001.118468
ATS Statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:1117.
DOI: https://doi.org/10.1164/ajrccm.166.1.at1102
Balashov K, Ehrmann Feldman D, Savard S, et al. Percent predicted value for the 6-minute walk test: using norm-referenced equations to characterize severity in persons with CHF. J Card Fail 2008;14:75-81.
DOI: https://doi.org/10.1016/j.cardfail.2007.09.005
Emami A, Saitoh M, Valentova M, et al. Comparison of sarcopenia and cachexia in men with chronic heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF). Eur J Heart Fail 2018;20:1580-7.
DOI: https://doi.org/10.1002/ejhf.1304
Dodds RM, Syddall HE, Cooper R, et al. Grip strength across the life course: normative data from twelve british studies. PLoS One 2014;9:e113637.
DOI: https://doi.org/10.1371/journal.pone.0113637
Kroenke K, Spitzer RL, Williams JB. The PHQ‐9: validity of a brief depression severity measure. J Gen Intern Med 2001;16:606-13.
DOI: https://doi.org/10.1046/j.1525-1497.2001.016009606.x
Löwe B, Spitzer RL, Gräfe K, et al. Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians' diagnoses. J Affect Disord 2004;78:131-40.
DOI: https://doi.org/10.1016/S0165-0327(02)00237-9
Hammash MH, Hall LA, Lennie TA, et al. Psychometrics of the PHQ-9 as a measure of depressive symptoms in patients with heart failure. Eur J Cardiovasc Nurs 2013;12: 446-53.
DOI: https://doi.org/10.1177/1474515112468068
Ware J, Kosinski MM, Keller S. A 12-item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996;34:220-33.
DOI: https://doi.org/10.1097/00005650-199603000-00003
Gandek B, Ware JE, Aaronson NK, et al. Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. J Clin Epidemiol 1998;51:1171-8.
DOI: https://doi.org/10.1016/S0895-4356(98)00109-7
Group EuroQol. EuroQol - a new facility for the measurement of health-related quality of life. Health Policy 1990;16:199-208.
DOI: https://doi.org/10.1016/0168-8510(90)90421-9
Brooks R, Rabin R, De Charro F. The measurement and valuation of health status using EQ-5D: a European perspective: evidence from the Euroqol Biomed Research Programme. Dordrecht, Springer; 2013.
Boczor S, Daubmann A, Eisele M, Blozik E, Scherer M. Quality of life assessment in patients with heart failure: validity of the German version of the generic EQ-5D-5L™. BMC Public Health 2019;19:1464.
DOI: https://doi.org/10.1186/s12889-019-7623-2
Ware JE, Snow KK, Kosinski MG. SF-36 health survey. Manual and interpretation guide. Boston, The Health Institute, New England Medical Center; 1993.
Müller-Nordhorn J, Roll S, Willich SN. Comparison of the short form (SF)-12 health status instrument with the SF-36 in patients with coronary heart disease. Heart 2004;90:523-7.
DOI: https://doi.org/10.1136/hrt.2003.013995
Prevolnik Rupel V, Srakar A, Rand K. Valuation of EQ-5D-3l health states in Slovenia: VAS based and TTO based value sets. Zdr Varst 2019;59:8-17.
DOI: https://doi.org/10.2478/sjph-2020-0002
Diener ED, Emmons RA, Larsen RJ, Griffin S. The Satisfaction with life scale. J Pers Assess 1985;49:71-5.
DOI: https://doi.org/10.1207/s15327752jpa4901_13
Pavot W, Diener E. Review of the Satisfaction with life scale. Psycol Assess 1993;5:164-72.
DOI: https://doi.org/10.1037//1040-3590.5.2.164
Meyer C, Rumpf HJ, Hapke U, John U. Impact of psychiatric disorders in the general population: satisfaction with life and the influence of comorbidity and disorder duration. Soc Psychiatry Psychiatr Epidemiol 2004;39:435-41.
DOI: https://doi.org/10.1007/s00127-004-0755-3
Rosengren L, Jonasson SB, Brogårdh C, Lexell J. Psychometric properties of the Satisfaction with life scale in Parkinson's disease. Acta Neurol Scand 2015;132:164-70.
DOI: https://doi.org/10.1111/ane.12380
Serafini G, Pompili M, Innamorati M, et al. The impact of anxiety, depression, and suicidality on quality of life and functional status of patients with congestive heart failure and hypertension: an observational cross-sectional study. Prim Care Companion J Clin Psychiatry 2010;12:pcc09m00916.
DOI: https://doi.org/10.4088/PCC.09m00916gry
Graham JW. Missing data analysis: making it work in the real world. Annu Rev Psychol 2009;60:549-76.
DOI: https://doi.org/10.1146/annurev.psych.58.110405.085530
Evangelista LS, Moser DK, Westlake C, Hamilton MA, Fonarow GC, Dracup C. Impact of obesity on quality of life and depression in patients with heart failure. Eur J Heart Fail 2006;8:750-5.
DOI: https://doi.org/10.1016/j.ejheart.2006.02.004
Nesbitt T, Doctorvaladan S, Southard J, et al. Correlates of quality of life in rural patients with heart failure. Circ Heart Fail 2014;7:882-7.
DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.113.000577
Peters-Klimm F, Kunz CU, Laux G, Szecsenyi J, Müller-Tasch T. Patient- and provider-related determinants of generic and specific health-related quality of life of patients with chronic systolic heart failure in primary care: a cross-sectional study. Health Qual Life Outcomes 2010;8:98.
DOI: https://doi.org/10.1186/1477-7525-8-98
Mårtensson J, Dracup K, Canary C, Fridlund B. Living with heart failure: depression and quality of life in patients and spouses. J Heart Lung Transplant 2003;22:460-67.
DOI: https://doi.org/10.1016/S1053-2498(02)00818-5
Cohen J. A power primer. Psychol Bull 1992;112:155-9.
DOI: https://doi.org/10.1037//0033-2909.112.1.155
Dickens C, Cherrington A, McGowan L. Depression and health-related quality of life in people with coronary heart disease: a systematic review. Eur J Cardiovasc Nurs 2012;11:265-75.
DOI: https://doi.org/10.1177/1474515111430928
Al Sayah F, Ohinmaa J, Johnson JA. Screening for anxiety and depressive symptoms in type 2 diabetes using patient-reported outcome measures: comparative performance of the EQ-5D-5L and SF-12v2. MDM Policy Pract 2018;3:2381468318799361.
DOI: https://doi.org/10.1177/2381468318799361
de Jonge P, Spijkerman TA, van den Brink RHS, Ormel J. Depression after myocardial infarction is a risk factor for declining health-related quality of life and increased disability and cardiac complaints at 12 months. Heart 2006;92:32-9.
DOI: https://doi.org/10.1136/hrt.2004.059451
Volz A, Schmid JP, Zwahlen M, Kohls S, Saner H, Barth J. Predictors of readmission and health-related quality of life in patients with chronic heart failure: a comparison of different psychosocial aspects. J Behav Med 2011;34:13-22.
DOI: https://doi.org/10.1007/s10865-010-9282-8
Giannitsi S, Bougiakli M, Bechlioulis A, Kotsia A, Michalis LK, Naka KK. 6-minute walking test: a useful tool in the management of heart failure patients. Ther Adv Cardiovasc Dis 2019;13:1753944719870084.
DOI: https://doi.org/10.1177/1753944719870084
Vitale C, Jankowska E, Hill L, et al. Heart Failure Association/European Society of Cardiology position paper on frailty in patients with heart failure. Eur J Heart Fail 2019;21:1299-305.
DOI: https://doi.org/10.1002/ejhf.1611
How to Cite
Sedlar Kobe, N., Omersa, D., Lainscak, M., & Farkas, J. (2024). Depression, health-related quality of life and life satisfaction in patients with heart failure. Global Cardiology, 2(3). https://doi.org/10.4081/cardio.2024.47
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